Genetic control of cutaneous basophil hypersensitivity
نویسندگان
چکیده
CBH to DNP-GL could be elicited only in responder guinea pigs which possess the genetic ability to develop classic delayed type hypersensitivity to DNP-PLL, the response to which is governed by the same gene. Since the defect in nonresponder animals seems to reside at the level of their T cells and not B cells, these results lend support to the contention that CBH, as well as DH, is dependent on and probably mediated by T cells.
منابع مشابه
The Effect of Threonine and Vitamin A on Immune System in Broiler Chickens
Two independent experiments were conducted with broilers to determine the effect of threonine and vitamin A on immune system. In first experiment, dietary treatments contained 0.8%, 0.87%, 0.94 % and 1.01 % total threonine. In second experiment, diets were as follows: basal diet without vitamin A; basal diet plus 1500 IU/Kg vitamin A; basal diet plus 6250 IU/Kg vitamin A; basal diet plus 11000 ...
متن کاملThe Effect of Threonine and Vitamin A on Immune System in Broiler Chickens
Two independent experiments were conducted with broilers to determine the effect of threonine and vitamin A on immune system. In first experiment, dietary treatments contained 0.8%, 0.87%, 0.94 % and 1.01 % total threonine. In second experiment, diets were as follows: basal diet without vitamin A; basal diet plus 1500 IU/Kg vitamin A; basal diet plus 6250 IU/Kg vitamin A; basal diet plus 11000 ...
متن کاملSuppression of T cell-mediated cutaneous basophil hypersensitivity by serum from guinea pigs immunized with mycobacterial adjuvant
Guinea pigs immunized with protein antigens emulsified with complete Freund's adjuvant (CFA) and skin tested at 3-4 wk have classical tuberculin-type delayed hypersensitivity (DH) reactions with few basophils present. However, recipients of T cells from these animals have delayed responses containing large basophil infiltrates and thus resemble basophil-rich cutaneous basophil hypersensitivity ...
متن کاملCutaneous Basophil Hypersensitivity
Delayed onset erythematous skin reactions elicited in guinea pigs early in the course of sensitization with azobenzenearsonate-protein conjugates or with protein antigens in incomplete Freund's adjuvant or in saline were found to have a characteristic morphology which sets them apart from delayed hypersensitivity and the classic antibody mediated reactions. The principle feature was massive der...
متن کاملCutaneous Basophil (jones-mote) Hypersensitivity after "tolerogenic" Doses of Intravenous Ovalbumin in the Guinea Pig
Cutaneous basophil hypersensitivity (CBH) was studied for tolerogenic requirements. Graded doses of intravenous ovalbumin (OA) were given to guinea pigs which were subsequently immunized appropriately to produce CBH, classic delayed hypersensitivity (classic DH), and/or antibodies of both passive cutaneous anaphylaxis (PCA) and hemolytic types. Results showed that doses of intravenous antigen s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 143 شماره
صفحات -
تاریخ انتشار 1976